Using Ultrapure Water in Hemodialysis Delays Carpal Tunnel Syndrome
| Autor: | T. Merzouk, C Durand, Yvon Berland, Jaber K, R. Purgus, M. Baz, Andrieu D, A. Ragon, M. Olmer, J. P. Reynier |
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| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Group ii 030232 urology & nephrology Biomedical Engineering Medicine (miscellaneous) Bioengineering Stimulation 030204 cardiovascular system & hematology Gastroenterology Biomaterials Hemodialysis Solutions 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Carpal tunnel syndrome business.industry Beta-2 microglobulin Interleukin General Medicine medicine.disease Surgery Tumor necrosis factor alpha Hemodialysis business |
| Zdroj: | The International Journal of Artificial Organs. 14:681-685 |
| ISSN: | 1724-6040 0391-3988 |
| Popis: | Since 1977, our patients have undergone chronic HD with ultra-pure dialysate (UPD), defined as having endotoxin levels below 0.008 ng/ml and less than 1 bacteria/ml of dialysate. We evaluated the incidence of carpal tunnel syndrome (CTS) in three groups of patients. Group I (GI), 84 patients, dialysed for 6.1 ± 3.2 years (mean ± SD) with UPD only; Group II (GII), 39 patients, first dialysed for 3.7 ± 2.3 years with non-UPD and afterwards for 8.4 ± 2.1 years with UPD; Group III (G III), 103 patients treated for 6 ± 5.9 years exclusively with non-UPD. All patients were dialysed with cuprophan or cellulose acetate membranes. Results, expressed by Kaplan-Meier actuarial survival curves as the percent of patients without CTS, show that CTS occurred significantly less in GI than in GIII. This may be due to less stimulation of monocytes resulting from the absence of bacteria, endotoxins and pyrogens in the dialysate which would reduce the stimulation of cytokines release, interleukin 1 and 6, and tumor necrosis factor, known to stimulate β2 microglobulin synthesis. |
| Databáze: | OpenAIRE |
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