Neuroinflammation in Synucleinopathies
| Autor: | Jun Sung Lee, Somin Lim, Seung-Jae Lee, Yewon Chun |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Synucleinopathies Parkinson's disease Microglia Dementia with Lewy bodies business.industry General Neuroscience Inflammation Disease medicine.disease Pathology and Forensic Medicine 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure medicine Synuclein Neurology (clinical) medicine.symptom business Neuroscience 030217 neurology & neurosurgery Neuroinflammation |
| Zdroj: | Brain Pathology. 26:404-409 |
| ISSN: | 1015-6305 |
| DOI: | 10.1111/bpa.12371 |
| Popis: | The causes of most neurodegenerative diseases are attributed to multiple genetic and environmental factors interacting with one another. Above all, inflammation in the nervous system has been implicated in many neurodegenerative diseases. Still, the roles of neuroinflammation in disease mechanisms and the triggers of inflammatory responses in disease-inflicted brain tissues seem to remain unclear. This review will examine previous studies that had been done from genetic, pathological and epidemiological perspectives. These studies assess the involvement of neuroinflammation in synucleinopathies, a group of neurodegenerative diseases that are characterized by deposition of α-synuclein aggregates such as Parkinson's disease, dementia with Lewy bodies and multiple system atrophy. The review will also discuss the role of α-synuclein aggregates in triggering inflammatory responses from glial cells. It is expected that a precise assessment of the roles and mechanisms of neuroinflammation in neurodegenerative diseases will pave the way for the development of disease-modifying drugs. |
| Databáze: | OpenAIRE |
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