Bronchial Carcinoids with S-100 Positive Sustentacular Cells
| Autor: | B. Frigo, Mosca L, B.C. Shiro, N. Carboni, Gene P. Siegal, Gianluigi Arrigoni, Mattia Barbareschi, E. Wilander, Elena Leonardi |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
endocrine system
Pathology medicine.medical_specialty endocrine system diseases Glial fibrillary acidic protein biology Myoepithelial cell Chromogranin A Vimentin Cell Biology medicine.disease digestive system diseases Pathology and Forensic Medicine medicine.anatomical_structure Dysplasia biology.protein medicine Intermediate filament neoplasms Neuroendocrine cell Histiocyte |
| Zdroj: | Pathology - Research and Practice. 186:212-222 |
| ISSN: | 0344-0338 |
| DOI: | 10.1016/s0344-0338(11)80538-8 |
| Popis: | Fourty-six bronchial carcinoids, twelve tumourlets and twenty areas of neuroendocrine cell dysplasia (NED) were immunohistochemically evaluated for various neuroendocrine markers, S-100 protein (S-100), myelin basic protein, intermediate filaments, actin, Leu-7 and several neurohormonal polypeptides. Eighteen of the bronchial carcinoids (39.1%) showed a biphasic cell pattern, with abundant stellate-shaped S-100 positive cells (SC). SC were not reactive for chromogranin A, myelin basic protein, cytokeratins, neurofilaments, glial fibrillary acidic protein or actin, and were only occasionally weakly positive for vimentin. SC were not detected in the tumourlets nor in the NED observed. For comparison a group of other neuroendocrine tumours (11 gastrointestinal carcinoids, 4 pheochromocytomas and 4 paragangliomas) were immunostained for S-100, chromogranin A and actin. SC similar to the ones detected in the bronchial carcinoids could be detected in appendiceal carcinoids, paragangliomas and in two out of four pheochromocytomas. Our present data are in keeping with a Schwannian/sustentacular nature of SC rather than that of a histiocytic or myoepithelial nature. We suggest that SC-rich bronchial carcinoids are biphasic tumours, which could be designed "paraganglioid" bronchial carcinoids. The relationship between SC-rich bronchial carcinoids and tumourlets/NED is a matter of further investigation: SC-rich bronchial carcinoids may either differentiate in a biphasic pattern during tumoural growth or may not be histogenetically related to tumourlets. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|