Practical application of new catalytic methods: a concise synthesis of a potent PDE IV inhibitor

Autor:	David L. Hughes, Arash Soheili, Charles Bazaral, Jennifer Albaneze-Walker, Shawn A. Springfield, Peter G. Dormer, Scott S. Ceglia, Jerry A. Murry
Rok vydání:	2005
Předmět:	inorganic chemicals Organic Chemistry chemistry.chemical_element Highly selective Biochemistry Combinatorial chemistry Catalysis chemistry.chemical_compound chemistry Drug Discovery Pyridine Side chain Organic chemistry Carbonylation Palladium
Zdroj:	Tetrahedron. 61:6330-6336
ISSN:	0040-4020
Popis:	An efficient synthesis of a potent PDE IV inhibitor 1 is described. The synthesis is highlighted by two practical and efficient catalytic reactions: a highly selective catalytic palladium mediated carbonylation of the pyridine side chain and an efficient palladium-catalyzed Suzuki–Miyaura coupling of a chloropyridine- N -oxide.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::55b66e10d6fc62184c507cd4b17a37c3 https://doi.org/10.1016/j.tet.2005.03.143 Zobrazit plný text záznamu Full Text from ScienceDirect