A rare case of pseudohypoparathyroidism
| Autor: | A. V. Dreval, E. V. Kornilova, V. A. Gubkina, T. S. Kamynina |
|---|---|
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Problems of Endocrinology. 45:38-39 |
| ISSN: | 2308-1430 0375-9660 |
| DOI: | 10.14341/probl11704 |
| Popis: | Pseudohypoparathyroidism (PGPT) - Albright's hereditary osteodystrophy is a sex-related disease rarely seen in medical practice. Inherited by the dominant type. It is caused by insensitivity of the kidneys and bones to parathyroid hormone (PG), which is secreted in normal or slightly elevated amounts [6, 10]. GH may not have a specific effect on cells due to pathology of GH receptors, impaired expression of information RNA synthesis by an unchanged hormone-receptor complex, the presence of pathological components of adenylate cyclase, pathological AMP-dependent protein kinase, or a defect in the synthesis of kinase substrates in the presence of circulating GH antagonists [5, 10 ]. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|