Isolation of an Ecotropic Porcine Endogenous Retrovirus PERV-C from a Yucatan SLA D/D Inbred Miniature Swine

Autor:	Michael Rodrigues Costa, Nicole Fischer, Antonia Gronewold, Barbara Gulich, Antonia W. Godehardt, Ralf R. Tönjes
Rok vydání:	2023
Předmět:	Virology Insect Science Immunology Microbiology
Zdroj:	Journal of Virology. 97
ISSN:	1098-5514 0022-538X
Popis:	Yucatan SLA D/D haplotype miniature swine are candidates as organ donors for xenotransplantation. A full-length replication-competent PERV-C provirus was characterized. The provirus was chromosomally mapped in the pig genome. In vitro , the virus showed increased infectivity compared to other functional PERV-C isolates. Data may be used for targeted knockout to generate PERV-C free founder animals.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::55b1be5a2675bfeba094b5c62b7a7f70 https://doi.org/10.1128/jvi.00062-23 Zobrazit plný text záznamu