Significant joint-destructive association of HLA-DRB1*04:05 independent of DAS28 in rheumatoid arthritis
| Autor: | Katsunori Ikari, Wataru Yamamoto, Chikashi Terao, Tsuneyo Mimori, Atsuo Taniguchi, Motomu Hashimoto, Hideaki Tsuji, Moritoshi Furu, Koichiro Ohmura, Koichiro Yano, Takao Fujii, Hiromu Ito, Hisashi Yamanaka |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
musculoskeletal diseases
0301 basic medicine Immunology Arthritis Human leukocyte antigen General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Rheumatology immune system diseases Severity of illness medicine Immunology and Allergy Rheumatoid factor Allele skin and connective tissue diseases 030203 arthritis & rheumatology biology business.industry Hla drb1 04 medicine.disease 030104 developmental biology Rheumatoid arthritis biology.protein Antibody business |
| Zdroj: | Annals of the Rheumatic Diseases. 78:284-286 |
| ISSN: | 1468-2060 0003-4967 |
| DOI: | 10.1136/annrheumdis-2018-214022 |
| Popis: | Preventing joint destruction is one of the challenges in rheumatoid arthritis (RA).1 Presence of two antibodies, namely, rheumatoid factor (RF) and cyclic citrullinated peptide antibodies (CCPs), is one of the major correlates of joint destruction.2 We recently showed the association between the progression of joint destruction and HLA-DRB1*04:05, which is independent from CCP positivity.3 HLA-DRB1*04:05 is one of shared epitope (SE) allele carrying common amino acid sequences at position 70–74 frequently found in Japanese and rarely observed in Europeans. Importantly, we showed that SE alleles other than DRB1*04:05 did not show independent associations from CCP.3 Based on the unique characteristics of HLA-DRB1*04:05, we hypothesised that HLA-DRB1*04:05 might lead to high disease activity not fully captured by Disease Activity Acore 28 (DAS28) and that it independently of DAS28 determines radiographic progression in patients with anti-CCP-positive RA (figure 1A). Figure 1 HLA-DRB1*04:05 showed a significant association with SHS independently of DAS28. (A) … |
| Databáze: | OpenAIRE |
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