Complex of tris(2-hydroxyethyl)amine with zinc bis[(2-methylphenoxy)acetate] as an aortic cholesterol esterase inhibitor in the experiment

Autor:	I. V. Zhigacheva, M. M. Rasulov, P. A. Storozhenko
Rok vydání:	2021
Předmět:	Tris chemistry.chemical_compound Aqueous solution chemistry Biochemistry Cholesterol Hydrolase System stability chemistry.chemical_element Amine gas treating General Chemistry Zinc Cholesterol Esterase
Zdroj:	Russian Chemical Bulletin. 70:1404-1407
ISSN:	1573-9171 1066-5285
Popis:	The intramuscular administration of the complex of tris(2-hydroxyethyl)amine with zinc bis[(2-methylphenoxy)acetate] (Zitrimin), as an aqueous solution in a dose of 10 mg (kg of animal weight)−1 for 2 months decreases activity of lysosomal lipolytic hydrolase (EC 3.1.1), cholesterol esterase (EC 3.1.1.13). Hence, the previously unknown feature of Zitrimin, that is, the ability to inhibit cholesterol esterase, attests to both structural and functional disorders of subcellular structures during development of atherosclerosis. The agents active towards such reactions can be useful in this case. Owing to the new properties, Zitrimin can be used to increase the vascular system stability to cholesterol during the atherosclerotic process. This expands the scope of applicability of this compound and gives prospects for development of new Zitrimin-based drugs for preventing the atherosclerotic vascular changes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::55af408e840f823f12a5c52fa0f13f7d https://doi.org/10.1007/s11172-021-3231-2 Zobrazit plný text záznamu Full text from SpringerLink