| Autor: |
Takahiro Takazono, Masato Tashiro, Tomotaro Wakamura, Koichi Izumikawa, Ai Tsuyuki, Yuki Ota, Yoko Obata, Tomoya Nishino, Taiga Miyazaki, Yui Shiozawa |
| Rok vydání: |
2021 |
| Předmět: |
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| DOI: |
10.21203/rs.3.rs-405131/v1 |
| Popis: |
Background: Acute kidney injury (AKI) often develops during the administration of liposomal amphotericin B (L-AMB), a broad-spectrum antifungal drug. However, clinical recovery approaches for AKI patients administered L-AMB have not been well established.Methods: A retrospective analysis was conducted using data obtained from hospitals throughout Japan. AKI was defined as a ≥1.5-fold increase within 7 days or ≥0.3 mg/dL increase within 2 days in serum creatinine. Renal recovery was defined as a return to creatinine levels below those recorded before the onset of AKI.Results: Herein, 189 patients had developed AKI following L-AMB administration. Of them, 153 were subsequently assessed to determine the trend in creatinine level after AKI and 90 patients were assessed for renal recovery. Patients administered ≥10 mL/kg daily fluid for 7 consecutive days from the onset of AKI had a 63% recovery rate relative to patients that did not receive infusion (35% recovery rate (P = 0.053)). Although extending the fluid infusion period beyond 7 days did not result in consistent improvement in renal recovery rates, daily fluid volume was found to be positively correlated with renal recovery (P = 0.043). On average, patients administered daily fluid infusions of ≥10 mL/kg had greater reductions in minimum creatinine levels for the first 7 days after AKI compared to patients that did not receive daily fluid infusions. After 7 days of fluid infusion, the mean minimum creatinine levels decreased by 0.21 mg/dL relative to 0.16 mg/dL for patients that did not receive daily fluid infusions.Conclusions: Seven consecutive days of daily fluid infusion from the onset of AKI may promote renal recovery from AKI in patients administered L-AMB, with daily fluid volume positively correlating with the incidence of renal recovery. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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