The German Transregional Collaborative Research Centre ‘Inflammatory Cardiomyopathy – Molecular Pathogenesis and Therapy’
| Autor: | Wolfgang Hoffmann, Karin Klingel, Uwe Kühl, M. Schmidt, J. v. Schlippenbach, H.P. Schultheiss, S. Schwedler, A. Angelow, Stephan B. Felix, Reinhard Kandolf, Dirk Lassner, H. Vogt, K. Stangl, C. Havemann, Kerstin Weitmann, A. Staudt |
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| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
business.industry Cardiomyopathy Molecular pathogenesis Follow up studies medicine.disease language.human_language Clinical study German Research centre medicine language Pharmacology (medical) Cooperative behavior Medical emergency Health behavior Cardiology and Cardiovascular Medicine Intensive care medicine business |
| Zdroj: | Cardiology. 113:222-230 |
| ISSN: | 1421-9751 0008-6312 |
| DOI: | 10.1159/000203404 |
| Popis: | Objectives: This report focuses on the design and methods of the 3-centre clinical study of the Transregional Collaborative Research Centre ‘Inflammatory Cardiomyopathy – Molecular Pathogenesis and Therapy’, which aims to establish a comprehensive research registry on the diagnostics, therapy and disease outcomes of patients with inflammatory cardiomyopathy (CMi). The study goals are to investigate specific disease sub-entities and to develop standardised strategies for diagnostics and treatment. Methods: All consecutive patients with clinically suspected CMi, post-myocarditic cardiomyopathy and acute myocarditis are included in the research registry. Cardiopulmonary functional tests, clinical and patient data are obtained at baseline and subsequent readmission appointments and are linked to allow for prospective follow-up. Co-morbidities, quality of life, health- related behaviour and sociodemographic variables are ascertained using uniform self-administered questionnaires. Present Status: By May 2008, 2,061 cases had been included in the research registry (1,300 data-sets completed). At registration, 335 patients were diagnosed with CMi. The mean age was 50 ± 13 years and the mean ejection fraction was 39.9 ± 15.8%. Conclusions: The broad range of the acquired molecular-biological, histological, immunohistological, clinical and patient data makes this the most comprehensive research registry on patients with CMi to date. |
| Databáze: | OpenAIRE |
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