Sedimentation study on the binding of fibrinogen or of antithrombin III with acidic polysaccharides including heparin
| Autor: | Akio Nakajima, Hiroko Sato, Eiji Nakanishi |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
chemistry.chemical_classification
Chromatography Polymers and Plastics Chemistry Antithrombin General Chemistry Heparin Buffer solution Sedimentation Condensed Matter Physics Fibrinogen Polysaccharide body regions chemistry.chemical_compound Dextran Biochemistry Materials Chemistry medicine Sulfate medicine.drug |
| Zdroj: | Polymer Bulletin. 24:429-435 |
| ISSN: | 1436-2449 0170-0839 |
| Popis: | The binding of fibrinogen with heparin and dextran sulfates, and of antithrombin III with heparin and dextran sulfate were investigated by sedimentation velocity method. From the measurement of fibrinogen-acidic polysaccharide systems, it was confirmed that heparin and low molecular weight dextran sulfate(DSC) forms soluble complexes with fibrinogen, though the amount bound of the latter was rather small compared with high molecular weight dextran sulfate(DSD). Antithrombin III was also found to be bound by heparin and DSC. The numbers of heparin molecules bound to one molecule of fibrinogen and antithrombin III were estimated to be 4.2 and 0.3, respectively. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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