Studies of the effects of new progestins from the pentarane series on viability, epidermal growth factor receptor expression, and apoptosis of cultured HeLa and MCF-7 cells

Autor:	V. V. Banin, K. A. Atroshkin, A. V. Kamernitskii, Inna S. Levina, A. V. Semeikin, L. E. Kulikova, N. L. Shimanovskii, V. B. Vetchinkina
Rok vydání:	2008
Předmět:	Pharmacology biology Chemistry Pregnane biology.organism_classification Cell biology HeLa chemistry.chemical_compound MCF-7 Apoptosis Cell culture Drug Discovery Cancer research biology.protein Growth factor receptor inhibitor Epidermal growth factor receptor A431 cells
Zdroj:	Pharmaceutical Chemistry Journal. 42:258-261
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-008-0102-1
Popis:	The effects of six new steroids of the pregnane series, with substituents at the 16α, 17α, and-or 3 and 19 positions of the steroid skeleton, on the viability of cultured breast cancer MCF-7 and cervical cancer HeLa cells were studied. The results showed that 3-keto-4-dehydrosteroids with a 16α,17α-spiropentane substituent and 3-keto-4-dehydro-16α,17α-cyclohexanopregnanes with 3-or 19-oxyimino groups decreased the viability of both types of cell culture. These compounds had negative influences on the expression of the epidermal growth factor receptor (EGFR) and induced apoptosis.
Databáze:	OpenAIRE
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