Palladium-Catalyzed Synthesis of Isoquinolinones via Sequential Cyclization and N-O Bond Cleavage of N-Methoxy-o-alkynylbenzamides

Autor:	Manita Jithunsa, Shoichi Sugita, Naoki Aoi, Tetsuya Miyoshi, Masafumi Ueda, Okiko Miyata
Rok vydání:	2013
Předmět:	inorganic chemicals chemistry Intramolecular force Organic Chemistry chemistry.chemical_element Regioselectivity Medicinal chemistry Bond cleavage Catalysis Palladium
Zdroj:	Synlett. 24:475-478
ISSN:	1437-2096 0936-5214
DOI:	10.1055/s-0032-1318159
Popis:	A palladium-catalyzed controlled 6-endo-dig cyclization process has been developed for the chemoselective synthesis of isoquinolin-1-ones from N-alkoxy-o-alkynylbenzamides. The mechanism and scope of the reaction have also been investigated. Deuterium-labeling studies were used to confirm the intramolecular 1,5-hydrogen shift as a key step in the transformation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5596c9d5eccdaab6374944d4713a8485 https://doi.org/10.1055/s-0032-1318159 Zobrazit plný text záznamu