Expression of Survivin in Oral Squamous Cell Carcinoma

Autor:	Norito Miyagi, Yuri Obi, Keiichi Tsukinoki, Tadahide Noguchi, Yoshinori Jinbu, Koichi Matsumoto, Tomohiro Senna, Mikio Kusama
Rok vydání:	2006
Předmět:	Pathology medicine.medical_specialty medicine.diagnostic_test business.industry Cancer Inhibitor of apoptosis medicine.disease medicine.anatomical_structure Tongue Biopsy Survivin Medicine Immunohistochemistry Basal cell business Gingival cancer
Zdroj:	Oral Medicine & Pathology. 11:41-44
ISSN:	1882-1537 1342-0984
Popis:	Survivin is a new and structurally unique member of the inhibitor of apoptosis family, expressed in all of the most common human cancers. We performed immunohistochemical staining of survivin and analyzed the relation with the clinicopathologic characteristics in human oral cancers. Oral biopsy specimens of 19 cases (12 men and 7 women) of oral cancer were used. The overall survivin positivity was 58%. The percentage of survivin-positive specimens in the T1+T2 group was significantly higher than that in the T3+T4 group (P=0.024) and the percentage of survivin-positive specimens in the N0 group was also significantly higher than that in the N+group (P=0.027). A slightly higher percentage of survivin-positive specimens was observed in the gingival cancer group compared with the tongue cancer group (P=0.059) and the percentage of survivin-positive specimens in the CR+PR group was also slightly higher than that in the NC group (P=0.06). Survivin was preferentially expressed in non-advanced, non-metastatic, and chemotherapy-sensitive oral squamous cell carcinoma.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::558c5172fb5a53bb8e332dbad633eb6d https://doi.org/10.3353/omp.11.41 Zobrazit plný text záznamu