Synthesis of Ugi 4-CR and Passerini 3-CR Adducts under Mechanochemical Activation

Autor:	Luis A. Polindara-García, Eusebio Juaristi
Rok vydání:	2016
Předmět:	Green chemistry Grinding process 010405 organic chemistry Chemistry Isocyanide Organic Chemistry 010402 general chemistry 01 natural sciences Environmentally friendly 0104 chemical sciences Adduct chemistry.chemical_compound Mechanochemistry Atom economy Organic chemistry Physical and Theoretical Chemistry Ball mill
Zdroj:	European Journal of Organic Chemistry. 2016:1095-1102
ISSN:	1434-193X
DOI:	10.1002/ejoc.201501371
Popis:	The successful application of a mechanochemical activation strategy that employs high-speed ball milling (HSBM) conditions for isocyanide-based multicomponent reactions (IMCRs) was developed. The syntheses of valuable Ugi (by a liquid-assisted grinding process) and Passerini (under solvent-free conditions) adducts were achieved by using this method. The protocol disclosed herein allows for the modular synthesis of various compounds according to green chemistry principles, specifically, environmentally friendly conditions, high atom economy, and the absence of toxic byproducts.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::556ef88ef59f221530d367fb9c87b032 https://doi.org/10.1002/ejoc.201501371 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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