The transcription factor Bhlhe40 is a switch of inflammatory versus anti-inflammatory Th1 cell fate determination

Autor:	fang yu, Suveena Sharma, Dragana Jankovic, Pan Su, Sadiye Rieder, Stephen Porcella, Bing Sun, Jinfang (Jeff) Zhu
Rok vydání:	2017
Předmět:	Immunology Immunology and Allergy
Zdroj:	The Journal of Immunology. 198:223.6-223.6
ISSN:	1550-6606 0022-1767
DOI:	10.4049/jimmunol.198.supp.223.6
Popis:	Type 1 T helper (Th1) cells play a critical role in host defense against intracellular pathogens and in autoimmune diseases by producing a key inflammatory cytokine interferon (IFN)-γ; some Th1 cells can be anti-inflammatory through producing IL-10. However, the molecular switch for regulating the differentiation of inflammatory and anti-inflammatory Th1 cells is still elusive. Here we show that Bhlhe40-deficient CD4 Th1 cells produced less IFN-γ but substantially more IL-10 than wild type Th1 cells. Bhlhe40-mediated IFN-γ production was independent of transcription factor T-bet regulation. Mice with conditional deletion of Bhlhe40 in T cells succumbed to Toxoplasma gondii infection and blockage of IL-10 signaling during infection rescued these mice from death. Thus, our results demonstrate that transcription factor Bhlhe40 is a molecular switch for determining the fate of inflammatory and anti-inflammatory Th1 cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::556b9e368b59c8cc29e0abd0a02bb87e https://doi.org/10.4049/jimmunol.198.supp.223.6 Zobrazit plný text záznamu