Chiral stationary phases in concert with homologous chiral mobile phase additives: Push/pull model

Autor:	Caroline C. Bahler, Hannah L. Gray, Keith J. Duff, Rachael J. Gray
Rok vydání:	1993
Předmět:	Pharmacology Analyte Chemistry Stereochemistry Organic Chemistry Chiral stationary phase Catalysis Analytical Chemistry Structural homology Phase (matter) Drug Discovery Enantiomer Retention time Spectroscopy Push pull
Zdroj:	Chirality. 5:201-206
ISSN:	1520-636X 0899-0042
DOI:	10.1002/chir.530050402
Popis:	A new “push/pull” model has been developed to explain synergistic effects observed in a system in which a chiral stationary phase (CSP) is used in combination with its homologous chiral mobile phase additive (CMPA). The model predicts the beneficial CMPA enantiomer and the counterproductive CMPA enantiomer a priori. Thus, an (R)-CSP will obtain positive synergism from a homologous (S)-CMPA and negative synergism from a homologous (R)-CMPA. The reverse is true for an (S)-CSP. The importance of structural homology between the CSP and the CMPA is demonstrated. Furthermore, the analysis time is decreased relative to the use of a CSP alone, because the retention time of the analyte peaks decreases when the CMPAs are used. © 1993 Wiley-Liss, Inc.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5564e7ba68f14f64d1c6bf4f38aa3597 https://doi.org/10.1002/chir.530050402 Zobrazit plný text záznamu Plný text