A new series of bipyridine based chiral organocatalysts for enantioselective Henry reaction

Autor:	Veeramanoharan Ashokkumar, Ayyanar Siva, Kumaraguru Duraimurugan
Rok vydání:	2016
Předmět:	Nitroaldol reaction 010405 organic chemistry Chemistry Enantioselective synthesis Substrate (chemistry) General Chemistry 010402 general chemistry 01 natural sciences Catalysis 0104 chemical sciences Bipyridine chemistry.chemical_compound Materials Chemistry Organic chemistry
Zdroj:	New Journal of Chemistry. 40:7148-7156
ISSN:	1369-9261 1144-0546
DOI:	10.1039/c6nj01045h
Popis:	A series of binaphthol based chiral organocatalysts were synthesized and applied as metal-free organocatalysts in the enantioselective Henry reaction. These organocatalysts enabled the Henry reaction with a lower concentration of catalysts at room temperature affording the desired S- or undesired R-enantiomers. The formation of R- and S-enantiomers of β-nitroalcohol products strongly depends on the temperature/substrate inversion of configuration for the effective catalytic enantioselective Henry reaction in high yields (up to 97%) with excellent enantioselectivities (up to 99% ee).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::556430c6b9d0053f1347c05e643c6bde https://doi.org/10.1039/c6nj01045h Zobrazit plný text záznamu