The Hepatotoxic Effect of Sildenafil Citrate and Its Combination with Tramadol on Male Wistar Rats is Ameliorated with Vitamin E Supplementation
| Autor: | S. Okpa, C. E. Obeten, Augustine L. Udefa, Justina Nwandimma Nwangwa, P. M. Obi |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
musculoskeletal diseases
business.industry Sildenafil Hepatotoxic effect Vitamin e supplementation virus diseases General Medicine Pharmacology female genital diseases and pregnancy complications chemistry.chemical_compound chemistry immune system diseases hemic and lymphatic diseases Medicine Tramadol business medicine.drug |
| Zdroj: | Archives of Current Research International. :1-10 |
| ISSN: | 2454-7077 |
| Popis: | Aims: This study investigated the effect of vitamin E on serum liver enzymes and bilirubin concentrations in male Wistar rats treated with sildenafil citrate (SC) and a combination of SC and tramadol on the background that these drugs cause oxidative damage to the liver. Methods: Thirty male Wistar rats (180-200 g) were randomly divided into six groups (n=5) thus: control (0.2 ml vehicle – olive oil), SC-treated group (Sil) (10 mg/kg of SC), SC+tramadol-treated group (Sil+Tra) (10 mg/kg of SC and 20 mg/kg of tramadol), vitamin E-treated group (Vit E) (100mg/kg of vitamin E), SC+vitamin E-treated group (Sil+Vit E) (received SC and vitamin E) and SC+tramadol+vitamin E-treated group (Sil+Tra+Vit E) (received SC, tramadol and vitamin E). Drugs were administered orally once daily for four weeks after which blood samples were obtained and used to measure serum concentrations of liver enzymes (AST, ALT and ALP) and bilirubin. Results: Serum AST, ALT, ALP, total bilirubin (TB) and unconjugated bilirubin (UCB) concentrations were significantly (p |
| Databáze: | OpenAIRE |
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