Acute effects of cocaine and cannabis on response inhibition in humans: an ERP investigation
| Autor: | Janelle H. P. van Wel, Johannes G. Ramaekers, Desirée Spronk, Ellen R.A. de Bruijn, Robbert J. Verkes |
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| Rok vydání: | 2015 |
| Předmět: |
Drug
medicine.medical_specialty media_common.quotation_subject Medicine (miscellaneous) Nucleus accumbens Pharmacology Impulsivity 03 medical and health sciences 0302 clinical medicine Event-related potential medicine Psychiatry media_common biology Novelty seeking biology.organism_classification medicine.disease Crossover study 030227 psychiatry Substance abuse Psychiatry and Mental health Cannabis medicine.symptom Psychology 030217 neurology & neurosurgery |
| Zdroj: | Addiction Biology. 21:1186-1198 |
| ISSN: | 1355-6215 |
| DOI: | 10.1111/adb.12274 |
| Popis: | Substance abuse has often been associated with alterations in response inhibition in humans. Not much research has examined how the acute effects of drugs modify the neurophysiological correlates of response inhibition, or how these effects interact with individual variation in trait levels of impulsivity and novelty seeking. This study investigated the effects of cocaine and cannabis on behavioural and event-related potential (ERP) correlates of response inhibition in 38 healthy drug using volunteers. A double-blind placebo-controlled randomized three-way crossover design was used. All subjects completed a standard Go/NoGo task after administration of the drugs. Compared with a placebo, cocaine yielded improved accuracy, quicker reaction times and an increased prefrontal NoGo-P3 ERP. Cannabis produced opposing results; slower reaction times, impaired accuracy and a reduction in the amplitude of the prefrontal NoGo-P3. Cannabis in addition decreased the amplitude of the parietally recorded P3, while cocaine did not affect this. Neither drugs specifically affected the N2 component, suggesting that pre-motor response inhibitory processes remain unaffected. Neither trait impulsivity nor novelty seeking interacted with drug-induced effects on measures of response inhibition. We conclude that acute drug effects on response inhibition seem to be specific to the later, evaluative stages of response inhibition. The acute effects of cannabis appeared less specific to response inhibition than those of cocaine. Together, the results show that the behavioural effects on response inhibition are reflected in electrophysiological correlates. This study did not support a substantial role of vulnerability personality traits in the acute intoxication stage. |
| Databáze: | OpenAIRE |
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