| Autor: |
Marie C. LaRegina, Kym C. Tolman, William G. Doubek, John A. Stern, Carmine J. Coscia, Frank E. Johnson, K. J. Muller, Hirohumi Arakawa |
| Rok vydání: |
1991 |
| Předmět: |
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| Zdroj: |
Proceedings of the 3rd International Congress on Neo-Adjuvant Chemotherapy ISBN: 9782817807843 |
| DOI: |
10.1007/978-2-8178-0782-9_64 |
| Popis: |
Steady progress in the treatment of cancer has increased the proportion of longterm survivors, and delayed treatment toxicity such as infertility is becoming an important consideration. Despite many reports documenting the adverse effects of cytotoxic drugs on fertility in men [1], a practical method to avoid this is not currently available. We are investigating a mechanical approach to this problem, which we have termed testicular circulatory isolation (TCI). This consists of temporarily interrupting the blood supply to the testis during drug administration. In the rat, testicular injury due to doxorubicin is reduced by TCI [1]. TCI can partially protect male rats from drug-induced infertility [2], and no long-term testicular injury results from TCI [3]. We now report an investigation of the mechanism of this protective effect. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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