Simple and rapid spectrophotometric and titrimetric methods for the determination of ascorbic acid in pharmaceutical preparations

Autor:	M.M. Aly, Rafat M. Souliman, Moustafa K. Hassan
Rok vydání:	2007
Předmět:	chemistry.chemical_classification Absorbance chemistry.chemical_compound Chloroform Aqueous solution Chromatography chemistry Ferrocene General Engineering Salt (chemistry) General Medicine Ascorbic acid
Zdroj:	Journal of Chemical Technology and Biotechnology. 30:435-439
ISSN:	1935-181X 0142-0356
DOI:	10.1002/jctb.503300154
Popis:	Ascorbic acid in pharmaceutical preparations can be determined by either spectrophotometric or titrimetric methods by its reaction with ferricinium trichloroacetate at pH 3. The latter is quantitatively reduced to ferrocene. This is extracted by chloroform and its concentration calculated from the absorbance at 440 nm. Alternatively, an aqueous solution of ascorbic acid is titrated with that of the blue ferricinium salt which acts as an indicator. Vitamins, minerals, hormones, dextrose and coloured additives do not interfere with the reaction. Both methods are simple, rapid and sensitive.
Databáze:	OpenAIRE
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