| Popis: |
Atopic dermatitis (AD) is a chronic, inflammatory disorder associated with dry, scaly, and extremely itchy skin having complex pathophysiology. Mostly, symptomatic treatments are offered to AD that include skin moisturizers, antihistaminic, topical steroids, etc. Although exact pathophysiology of AD is not clear, it was reported that along with genetic factors, epidermis dysfunction, and immune system abnormalities, microbiome in the gut-skin axis also contributes for the progression of AD. The alteration in gut flora results in dysbiosis, an imbalance within natural microbiota which causes many health complications including AD. Probiotics are live microorganisms which support gut microbiota and elicit several health benefits when consumed. However, viability and stability of probiotics are the major concerns for their effective usage. Probiotics are available in various conventional dosage forms like tablet, capsules, sachets, oral liquids, etc. Additionally, they are also incorporated into controlled delivery systems using microencapsulation and lyophilization techniques which not only deliver required amount of probiotic at a targeted site but also significantly improve their sustainability. At present, several clinical trials are ongoing for different strains of probiotics and their relevance to microbiota. In the future, new routes and dosage forms can be explored for effective delivery of probiotics in management of AD. |
