Interleukin-1β, tumor necrosis factor-α levels and neutrophil elastase activity in peri-implant crevicular fluid

Autor: Tamer Ataoglu, Seyfullah Haliloglu, Nilgun Ozlem Alptekin, Behic Serpek, Ercan Durmuş, Mihtikar Gursel, Hanife Ataoglu
Rok vydání: 2002
Předmět:
Zdroj: Clinical Oral Implants Research. 13:470-476
ISSN: 0905-7161
DOI: 10.1034/j.1600-0501.2002.130505.x
Popis: The aim of this study was to determine interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) levels and neutrophil elastase (NE) activity in peri-implant crevicular fluid (PICF) of smoker and nonsmoker patients, and to investigate their relationships with clinical parameters. A total of 42 endosseous root-form dental implants of 14 patients were clinically examined by modified Plaque index (PI), modified Gingival index (GI) and probing depth (PD). Smoking habits of the patients were recorded. PICF of implants were collected by Periopaper strips and IL-1beta, TNF-alpha levels were determined by enzyme-linked immunosorbent assay (ELISA). NE was analyzed with a neutrophil specific chromogenic substrate, N-methoxysuccinyl-Ala-Ala-Pro-Val-p-nitroanilide. The cytokine and enzyme levels in PICF were expressed as total amount/activity and as concentrations. NE activity in PICF significantly correlated with GI and PD, and IL-1beta levels with GI and PICF volume (P 1) had higher levels of IL-1beta and NE activity than implants with noninflamed or slightly inflamed gingiva (GI 3 mm) was greater than the implants with shallow pockets (PD
Databáze: OpenAIRE