Investigation on Toxicity and Teratogenicity in Rats of a Retinoid-Polyamine Conjugate with Potent Anti-Inflammatory Properties
| Autor: | Theodoros Petridis, Katerina Grafanaki, Christina J. Malavaki, Christos G. Kostopoulos, Dimitra Giannakopoulou, Dionissios Papaioannou, Denis Drainas, Dionysios J. Papachristou, Vassiliki Stamatopoulou, George E. Magoulas, Helen Papadaki, Stathianna Douroumi, Nikos K. Karamanos |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Embryology Pituitary gland medicine.medical_specialty medicine.drug_class Health Toxicology and Mutagenesis Uterus Retinoic acid Toxicology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Prostate Internal medicine medicine Retinoid business.industry Thyroid Chorioallantoic membrane 030104 developmental biology medicine.anatomical_structure Endocrinology chemistry 030220 oncology & carcinogenesis Toxicity business Developmental Biology |
| Zdroj: | Birth Defects Research Part B: Developmental and Reproductive Toxicology. 107:32-44 |
| ISSN: | 1542-9733 |
| DOI: | 10.1002/bdrb.21170 |
| Popis: | Previous studies have shown that N(1),N(12)-bis(all-trans-retinoyl)spermine (RASP), a retinoid analog, inhibits RNase P activity and angiogenesis in the chicken embryo chorioallantoic membrane, demonstrates anti-tumor activity on prostate cancer cells, and acts as anti-inflammatory agent, being more effective and less toxic than all-trans retinoic acid. In an attempt to further characterize the biological profile of RASP, we tested its effects on organ toxicity and teratogenicity by daily oral gavage of RASP at a level of 50 mg/Kg of body weight in two generations of rats. We found that this compound does not induce changes to the body growth, the appearance of physical features, and the animal's reflexes. Additionally, no substantial histopathological lesions were found in brain, heart, lung, thymus, liver, thyroid gland, adrenal gland, pituitary gland, kidneys, spleen, skin, femora, prostate, testis, epididymis, vagina, uterus, and ovaries of RASP-treated animals. These results suggest RASP, as a promising lead compound for the treatment of several dermatological disorders and certain cancer types, has apparently minimal toxic side-effects as revealed in this two-generation reproduction study in rats. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text