Ternary Solubility Phase Diagrams of Mandelic Acid and N-Methylephedrine in Chiral Solvents with Different Carbon Chain Lengths
| Autor: | Chandrakant Ramkrishna Malwade, Heike Lorenz, Andreas Seidel-Morgenstern, Samuel Kofi Tulashie |
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| Rok vydání: | 2010 |
| Předmět: |
Chemistry
Inorganic chemistry technology industry and agriculture General Chemistry Condensed Matter Physics Mandelic acid Solvent chemistry.chemical_compound symbols.namesake symbols Organic chemistry General Materials Science Solubility Enantiomer N-Methylephedrine Ternary operation Raman spectroscopy Phase diagram |
| Zdroj: | Crystal Growth & Design. 10:4023-4029 |
| ISSN: | 1528-7505 1528-7483 |
| Popis: | Ternary solubility phase diagrams of mandelic acid and N-methylephedrine species in chiral solvents, (S)-methyl lactate, (S)-propyl lactate, and (S)-butyl lactate, have been determined. Solubility measurements were performed for enantiomeric compositions ranging from 50:50 mixtures to the pure enantiomers and temperatures ranging from 0 to 35 °C for mandelic acid and from 0 to 25 °C for N-methylephedrine, respectively. The ternary solubility phase diagrams of mandelic acid and N-methylephedrine showed symmetric behavior. It became obvious that increasing chain length of chiral solvents, i.e. from (S)-methyl lactate to (S)-butyl lactate, resulted in decreasing solubility. 1HNMR and Raman spectroscopy have been applied to characterize the solute-solvent interaction in the liquid phase for mandelic acid system. Molecular modeling calculations were performed for mandelic acid to get a deeper understanding of the solute−solvent interactions. The effect of the solvent on the shape of the solubility isotherms is... |
| Databáze: | OpenAIRE |
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