Transneuronal Dpr12/DIP-δ interactions facilitate compartmentalized dopaminergic innervation ofDrosophilamushroom body axons
| Autor: | Idan Alyagor, Victoria Berkun, Fabienne Reh, Hagar Meltzer, Eyal David, Bavat Bornstein, Hadas Keren-Shaul, Oren Schuldiner, Thomas Riemensperger |
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| Rok vydání: | 2019 |
| Předmět: |
0303 health sciences
media_common.quotation_subject Dopaminergic Biology biology.organism_classification Cell biology 03 medical and health sciences 0302 clinical medicine nervous system Mushroom bodies Immunoglobulin superfamily Drosophila (subgenus) Metamorphosis 030217 neurology & neurosurgery 030304 developmental biology media_common |
| DOI: | 10.1101/834515 |
| Popis: | SummaryThe mechanisms controlling wiring of neuronal networks are largely unknown. The stereotypic architecture of theDrosophilamushroom-body (MB) offers a unique system to study circuit assembly. The adult medial MB γ-lobe is comprised of a long bundle of axons that wires with specific modulatory and output neurons in a tiled manner defining five distinct zones. We found that the immunoglobulin superfamily protein Dpr12 is cell-autonomously required in γ-neurons for their developmental regrowth into the distal γ4/5 zones, where both Dpr12 and its interacting protein, DIP-δ, are enriched. DIP-δ functions in a subset of dopaminergic neurons that wire with γ-neurons within the γ4/5 zone. During metamorphosis, these dopaminergic projections arrive to the γ4/5 zone prior to γ-axons, suggesting that γ-axons extend through a prepatterned region. Thus, Dpr12/DIP-δ transneuronal interaction is required for γ4/5 zone formation. Our study sheds light onto molecular and cellular mechanisms underlying circuit formation within subcellular resolution. |
| Databáze: | OpenAIRE |
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