THE EFFICACY OF A TOPICAL SIALOGOGUE SPRAY CONTAINING 1% MALIC ACID IN PATIENTS WITH ANTIDEPRESSANT-INDUCED DRY MOUTH: A DOUBLE-BLIND, RANDOMIZED CLINICAL TRIAL
| Autor: | Javier Guardia, Maribel Cabrera-Ayala, Rafael Arcesio Delgado-Ruiz, José Luis Calvo-Guirado, Alejandro Uribe-Marioni, Antonio Aguilar-Salvatierra, Gerardo Gómez-Moreno |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Saliva business.industry Dentistry Placebo Dry mouth Gastroenterology law.invention Double blind Psychiatry and Mental health Clinical Psychology chemistry.chemical_compound Randomized controlled trial chemistry law Internal medicine medicine Antidepressant Malic acid Sialogogue medicine.symptom business |
| Zdroj: | Depression and Anxiety. 30:137-142 |
| ISSN: | 1091-4269 |
| DOI: | 10.1002/da.22017 |
| Popis: | Background One of the most important antidepressants side effects is dry mouth. The aim of this study was to evaluate the clinical efficacy of a topical sialogogue spray containing 1% malic acid on patients affected by dry mouth caused by antidepressants drug. Materials and methods This research took the form of a double-blind, randomized clinical trial at Faculty of Dentistry of University of Granada (Spain). Seventy participants with antidepressant-induced dry mouth were divided into two groups: for the first “intervention group” (35 subjects) a topical sialogogue spray (1% malic acid) was applied, while for the second “control group” (35 subjects), a placebo spray was applied; for both groups, the sprays were applied on demand during 2 weeks. The Dry Mouth Questionnaire (DMQ) was used to evaluate dry mouth symptoms before and after product/placebo application. Unstimulated and stimulated salivary flows rates, before and after application, were measured. Results Dry mouth symptoms improved after 1% malic acid topical spray application (p < .05). After 2 weeks of 1% malic acid application, unstimulated and stimulated salivary flows rates increased significantly (p < .05). Conclusions A sialogogue spray containing 1% malic acid improved dry mouth feeling of the patients suffering antidepressant-induced dry mouth and increased unstimulated and stimulated salivary flows rates. |
| Databáze: | OpenAIRE |
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