Quantitative assessment of preoperative risk factors for aggressive course of medullary thyroid carcinoma
| Autor: | Roman Chernikov, Juliya Karelina, Yurii Malyugov, Victor Mаkarin, I K Chinchuk, Natalia I. Timofeeva, A A Uspenskaya, A A Semenov, Nataliya Gorskaya, E. A. Valdina, Ilya Sablin, Dmitrii Buzanakov, E A Fedorov, Konstantin Novokshonov, Ilya Sleptsov, Svetlana Alekseeva, Aleksandr N. Bubnov, Anna Zolotukho, Dina V. Rebrova |
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| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
medicine.medical_specialty Medullary cavity business.industry medicine.medical_treatment Medullary thyroid cancer Cancer Retrospective cohort study medicine.disease Gastroenterology Primary tumor Thyroid carcinoma Endocrine surgery Oncology Calcitonin Internal medicine Medicine business |
| Zdroj: | Problems in oncology. 67:97-104 |
| ISSN: | 0507-3758 |
| Popis: | Objectives: to study the long-term results of surgical treatment of patients with medullary thyroid carcinoma and evaluate the significance of prognostic factors. Materials and methods: the continuous retrospective study included 169 patients with histologically confirmed medullary cancer who were initially operated at the Northwestern Center for Endocrinology and Endocrine Surgery of the SPbSU University Clinic from 2010 to 2016. They were divided into prognostic groups according to the level and dynamics of postoperative calcitonin and clinical manifestations of the disease. Results: The study allowed to assess the effect of predictive factors on the risks of progression and recurrence in medullary thyroid cancer. Size of the primary tumor more than 2 cm significantly increases the risk of disease progression (OR=6,56 (0.52-17.96) p=0,00001495). Invasion of the thyroid capsule and metastases to regional lymph nodes are even more important prognostic value as OR=49,08 (10.72-224.89), p=0,00000011 и OR=30,63 (9,75-96,27), p600 pg/ml affects the prognosis (OR=6,65 (2,53-17,59) p=0.01055). Its prognostic value is comparable to the size of the primary tumor and significantly less than the presence of regional and distant metastases. Conclusions: Unfavorable prognosis in 21 (12.4%) observed patients is associated not only with the presence of distant metastases, but also and independently with regional ones. |
| Databáze: | OpenAIRE |
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