A new model of depression induced by psychogenic stress

Autor:	Matitaishvili T, T. P. Damianidze, I Labadze, K. N. Chichinadze, Khananashvili M, I. N. Pantsulaya
Rok vydání:	2012
Předmět:	Forced swimming Tail Suspension Physiology Psychogenic disease Animal body Serotonin Psychology Biochemistry Neuroscience Ecology Evolution Behavior and Systematics Depression (differential diagnoses) Clinical psychology
Zdroj:	Journal of Evolutionary Biochemistry and Physiology. 48:181-188
ISSN:	1608-3202 0022-0930
DOI:	10.1134/s0022093012020077
Popis:	A new model of depression based on use of stressors of the psychogenic nature has been created. It turned out that laboratory rats in a special stress-camera were unable to elaborate bilateral reaction of active avoidance, which later on led to formation of their depression-like state. Development of such their state was confirmed by analysis of tests sensitive to depression: forced swimming and tail suspension, dynamics of the animal body mass and their behavior on the whole. This model has turned out to be sensitive to a selective inhibitor of the serotonin uptake—fluoxetine, which also confirms that our obtained model is the model of depression.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::553117334b19606371638bf3a0846aa4 https://doi.org/10.1134/s0022093012020077 Zobrazit plný text záznamu Plný text ve formátu PDF