Effects of CDX2 on prognosis and chemotherapy responsiveness in mismatch repair-deficient colorectal cancer
| Autor: | É. J. Ryan, B. Creavin, Y. L. Khaw, M. E. Kelly, H. M. Mohan, R. Geraghty, E. J. Ryan, R. Kennelly, A. Hanly, S. T. Martin, D. Fennelly, R. McDermott, D. Gibbons, P. R O'Connell, K. Sheahan, D. C. Winter |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oncology Prothrombin time Chemotherapy medicine.medical_specialty medicine.diagnostic_test Lymphovascular invasion business.industry Colorectal cancer medicine.medical_treatment Hazard ratio General Medicine Odds ratio Disease medicine.disease Chemotherapy regimen digestive system diseases 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Internal medicine embryonic structures medicine business |
| Zdroj: | BJS Open. 2:456-463 |
| ISSN: | 2474-9842 |
| DOI: | 10.1002/bjs5.91 |
| Popis: | Background Caudal-related homeobox transcription factor 2 (CDX2) is an intestine-specific transcription factor implicated in tumour differentiation, proliferation, cell adhesion and migration. Negative CDX2 status (CDX2-) is associated with worse prognosis in colorectal cancer and may identify high-risk stage II disease that benefits from adjuvant chemotherapy. This observational study investigated whether CDX2- is associated with prognosis or response to chemotherapy in the mismatch repair-deficient (dMMR) phenotype of colorectal cancer. Methods Patients with resectable dMMR colorectal cancer were eligible for inclusion. The prognostic and predictive value of CDX2 expression on the presence of lymph node metastasis (LNM) and survival was investigated. CDX2 status was determined via immunohistochemistry using the Leica Bond™ CDX2 (clone EP25) ready-to-use primary antibody. Results Some 235 of 238 consecutive dMMR tumours were assessed for CDX2 status. CDX2- was observed in 15·7 per cent of colorectal cancer. Interobserver agreement was excellent (κ = 0·863; P |
| Databáze: | OpenAIRE |
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