Phlolosides A–F, iridoids from Phlomis likiangensis with a carbonate ester substituent
| Autor: | Tao Cui, De-Huan Fu, Xu-Hong Li, Jing-Kun Wang, Li-He Lu, Zhaoyun Zhu, Yun-Biao Li, De-Song Wu, Qi Yao, Mei Shuangxi, Xiao-Hui Li |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Iridoid Glycosides
biology 010405 organic chemistry Stereochemistry Organic Chemistry Substituent biology.organism_classification 01 natural sciences Biochemistry Carbonate ester 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Phlomis chemistry Drug Discovery Organic chemistry Acid hydrolysis Single crystal |
| Zdroj: | Tetrahedron Letters. 58:3112-3118 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/j.tetlet.2017.06.078 |
| Popis: | Chemical study on the aerial parts of Phlomis likiangensis unearthed six new iridoid glycosides, phlolosides A–F ( 1 – 6 ), together with six known analogues ( 7 – 12 ). In the light of a combination of spectroscopic data, acid hydrolysis and single crystal X-ray diffraction analysis, the structures of 1 – 6 were determined. This is the first discovery of iridoid glycosides assembling a carbonate ester substituent group. All isolated compounds were assayed for cytotoxic and antibacterial activities, but were either inactive or very weakly active. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect