Plasma and brain pharmacokinetic profile of cannabidiol (CBD), cannabidivarine (CBDV), Δ9-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following oral and intraperitoneal administration and CBD action on obsessive–compulsive behaviour

Autor:	Serena Deiana, Barbara Pigliacampo, Shona Fleming, Akihito Watanabe, Naoki Amada, Marlene Arthur, Steve Close, Yuki Yamasaki, Patricia Dorward, Hilary Woodcock, Gernot Riedel, Bettina Platt
Rok vydání:	2011
Předmět:	Pharmacology Cannabigerol business.industry Tetrahydrocannabivarin Obsessive compulsive behaviour chemistry.chemical_compound chemistry Pharmacokinetics In vivo Pharmacodynamics medicine Systemic administration business Cannabidiol medicine.drug
Zdroj:	Psychopharmacology. 219:859-873
ISSN:	1432-2072 0033-3158
DOI:	10.1007/s00213-011-2415-0
Popis:	Rationale Phytocannabinoids are useful therapeutics for multiple applications including treatments of constipation, malaria, rheumatism, alleviation of intraocular pressure, emesis, anxiety and some neurological and neurodegenerative disorders. Consistent with these medicinal properties, extracted cannabinoids have recently gained much interest in research, and some are currently in advanced stages of clinical testing. Other constituents of Cannabis sativa, the hemp plant, however, remain relatively unexplored in vivo. These include cannabidiol (CBD), cannabidivarine (CBDV), Δ9-tetrahydrocannabivarin (Δ9-THCV) and cannabigerol (CBG).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5521f8636df431fe693b08bc9fa4e464 https://doi.org/10.1007/s00213-011-2415-0 Zobrazit plný text záznamu Full text from SpringerLink