Phenyliodine(III) Bis(trifluoroacetate) Mediated Synthesis of 6-Piperidinylpurine Homo-N-nucleosides Modified with Isoxazolines or Isoxazoles

Autor:	Konstantinos E. Litinas, Catherine Peperidou, Thomas Balalas, Dimitra Hadjipavlou-Litina
Rok vydání:	2015
Předmět:	Lipid peroxidation Solvent chemistry.chemical_compound chemistry Nitrile Organic Chemistry Oxide Organic chemistry Isoxazole Acetaldehyde oxime Catalysis Phenyliodine(III) bis(trifluoroacetate) Cycloaddition
Zdroj:	Synthesis. 48:281-292
ISSN:	1437-210X 0039-7881
DOI:	10.1055/s-0035-1560704
Popis:	The room temperature, 1,3-dipolar cycloaddition reactions of the nitrile oxide obtained from (6-piperidin-1-yl-9H-purin-9-yl)acetaldehyde oxime upon phenyliodine(III) bis(trifluoroacetate) treatment with excess unsaturated alcohols as solvent resulted in isoxazoline or isoxazole derivatives in almost quantitative yields. Analogous derivatives were prepared from the reactions of unsaturated phosphates. Preliminary biological tests indicated inhibition of lipid peroxidation for some of the examined compounds.
Databáze:	OpenAIRE
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