Production of In, Au, and Pt nanoparticles by discharge plasmas in water for assessment of their bio-compatibility and toxicity
| Autor: | Masaharu Shiratani, Miyuki Hirata, Takaaki Amano, Akiyo Tanaka, Kazunori Koga, Thapanut Sarinont |
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| Rok vydání: | 2016 |
| Předmět: |
010302 applied physics
Materials science Mechanical Engineering Kinetics Analytical chemistry Nanoparticle chemistry.chemical_element 02 engineering and technology Plasma Bio compatibility respiratory system 021001 nanoscience & nanotechnology Condensed Matter Physics Platinum nanoparticles 01 natural sciences chemistry Mechanics of Materials 0103 physical sciences Toxicity General Materials Science 0210 nano-technology Platinum Indium Nuclear chemistry |
| Zdroj: | MRS Advances. 1:1301-1306 |
| ISSN: | 2059-8521 |
| Popis: | Nanoparticles have great potential for biomedical applications such as early detection, accurate diagnosis, and personalized treatment of cancer. Assessment of bio-compatibility and toxicity of nanoparticles body is an emerging topic for these applications. To study kinetics of nanoparticles in body, we synthesized indium, gold and platinum nanoparticles in aqueous suspension using pulsed electrical discharge plasmas in water. The average size of synthesized primary nanoparticles for indium, gold, and platinum are 6.2 nm, 6.7 nm, and 5.4 nm, whereas the average size of secondary nanoparticles for indium, gold, and platinum are 315 nm, 72.3 nm, and 151 nm, respectively. Synthesized indium nanoparticles are transported from subcutaneous to serum and brain. The indium content in serum for the synthesized nanoparticles is much higher than that for the In2O3 nanoparticles of 150 nm in primary size. For gold and platinum nanoparticles, preliminary examination of intratracheal administration revealed that administration of synthesized nanoparticles with 10 mg/kg BW (body weight) may cause bleedings and/or emphysema in lung. |
| Databáze: | OpenAIRE |
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