| Autor: | Imants Meirovics, I. Kalnina |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Liposome
Sociology and Political Science Chemistry Clinical Biochemistry Analytical chemistry Biochemistry Fluorescence Peripheral blood mononuclear cell Benzanthrone Peripheral blood Clinical Psychology chemistry.chemical_compound Membrane Biophysics Law Spectroscopy Social Sciences (miscellaneous) |
| Zdroj: | Journal of Fluorescence. 9:27-32 |
| ISSN: | 1053-0509 |
| Popis: | Properties of benzanthrone aminoderivative ABM (conditional name) as a potential fluorescent probe were investigated. Spectral characteristics of the compound in different solvents as well as their binding to model lipid membranes (liposomes) and human peripheral blood mononuclear cells (lymphocytes; ly) were determined. The fluorescence was found to be sensitive polarity changes to the environment. Distinctions were observed in the spectral characteristics of the investigated compound when bounded to liposomes. It was established that spectral characteristics of ABM in cell suspension qualitatively characterize the structural and functional alterations of ly during pathological phenomena and correlate directly with the clinical view of disease. The ABM is shown to be a perspective in the screening for various pathologies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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