Laser hyperthermia of tumors using gold nanoparticles monitored by optical coherence tomography and acoustic thermometry

Autor: Elena V. Zagainova, N. N. Denisov, Vadim Elagin, Marina V. Shirmanova, Marina A. Sirotkina, Pavel Subochev
Rok vydání: 2011
Předmět:
Zdroj: Biophysics. 56:1102-1105
ISSN: 1555-6654
0006-3509
DOI: 10.1134/s0006350911060194
Popis: Local laser hyperthermia of grafted RShM-5 tumors in mice with the use of plasmon resonant gold nanoparticles has been carried out. Accumulation of particles in the tumor was monitored in vivo noninvasively by optical coherence tomography. Thereby it was determined that the maximal content of nanoparticles in the tumor was reached within 5 h after intravenous administration, and laser hyperthermia was performed at this time. Monitoring the tumor temperature during the treatment by IR thermography and acoustic thermometry showed that the nanoparticles provided efficient temperature elevation inside the tumor as well as more selective heating. Local laser hyperthermia with gold nanoparticles, but not the laser exposure alone, substantially inhibited tumor growth in several days after a single session.
Databáze: OpenAIRE
Externí odkaz: