Patterns of Distant Failure and Second Primary Cancers in Patients with Oropharyngeal Squamous Cell Carcinoma: Implications for Surveillance Methodology
| Autor: | E.F. Crandley, David C. Shonka, Edward B. Stelow, Paul W. Read, David D. Wilson, Mark J. Jameson, Austin J. Sim, Neil Majithia, Asal S. Rahimi |
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| Rok vydání: | 2014 |
| Předmět: |
Oncology
Chemotherapy medicine.medical_specialty animal structures medicine.diagnostic_test business.industry medicine.medical_treatment Distant metastasis Physical examination Intensity-modulated radiation therapy Second Primary Cancers Internal medicine medicine Physical exam In patient Oropharyngeal squamous cell carcinoma business |
| Zdroj: | Journal of Cancer Research Updates. 3 |
| ISSN: | 1929-2279 |
| DOI: | 10.6000/1929-2279.2014.03.03.5 |
| Popis: | Background: We analyzed the pattern of distant metastasis (DM) and secondary primary cancers (SPC) in patients with oropharyngeal squamous cell carcinoma (OPSCC) to develop surveillance guidelines. Methods: A retrospective review of 177 patients with OPSCC treated with intensity modulated radiation therapy ± chemotherapy between 2002 and 2012 was performed to characterize the rate, pattern, and timing of DM and SPC. Results: Sixteen patients (9.0%) developed DM and 9 patients (5.1%) developed a SPC. Overall, 24/177 patients (13.6%) developed a DM and/or SPC for a total of 27 events. 92.6% (25/27) of events were detectable on physical exam and/or chest CT. p16+ patients developed DM later than p16- tumors (23.4 months versus 8.7 months). Conclusions: Chest CT with physical examination detects the majority of DM and SPC in patients with OPSCC and would provide effective surveillance in these patients. A risk adapted surveillance strategy is proposed. |
| Databáze: | OpenAIRE |
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