Co-Ligand Induced Chiral Recognition of N-Thiophosphorylated Thioureas in Crystalline Ni(II) Complexes
| Autor: | Alexandra D. Voloshina, A. S. Sapunova, Anna P. Lyubina, Vladimir A. Alfonsov, K. E. Metlushka, Lyudmila N. Punegova, Olga N. Kataeva, K. A. Nikitina, Zilya Yamaleeva, Airat Kiiamov, Olga A. Lodochnikova, D. N. Sadkova, Kamil A. Ivshin, Oleg G. Sinyashin |
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| Rok vydání: | 2019 |
| Předmět: |
inorganic chemicals
010405 organic chemistry Ligand technology industry and agriculture Supramolecular chemistry Crystal growth General Chemistry 010402 general chemistry Condensed Matter Physics 01 natural sciences Single Crystal Diffraction 0104 chemical sciences law.invention Metal chemistry.chemical_compound Crystallography Enantiopure drug chemistry law visual_art Pyridine visual_art.visual_art_medium General Materials Science Crystallization |
| Zdroj: | Crystal Growth & Design. 19:4044-4056 |
| ISSN: | 1528-7505 1528-7483 |
| DOI: | 10.1021/acs.cgd.9b00446 |
| Popis: | The possibility was demonstrated to use metal coordination for the resolution of racemic chiral N-thiophosphorylated thioureas through controlling the stereochemistry of the complex formation and supramolecular chiral recognition during crystallization. A series of new Ni(II) complexes derived from chiral N-thiophosphorylated thioureas with 1,3-N,S-coordination were synthesized in enantiopure and racemic forms and characterized by X-ray single crystal diffraction. It was shown that square-planar centrosymmetric nickel ion coordination results in exclusive formation of meso-complexes from racemic ligands. The symmetry break of the nickel ion coordination by the introduction of pyridine co-ligand into the apical position promotes chiral recognition of the ligands upon complexation with formation of exclusively homochiral complexes. Further supramolecular recognition might be achieved by variation of crystal growth conditions, with racemic crystals being obtained at higher initial concentrations, including t... |
| Databáze: | OpenAIRE |
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