Porcine surfactant replacement therapy in newborns of 25-31 weeks’gestation: a randomized, multicentre trial of prophylaxis versus rescue with multiple low doses
| Autor: | H Walti, J Paris-Llado, Gérard Bréart, M Couchard |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Pediatrics
medicine.medical_specialty Respiratory distress business.industry Incidence (epidemiology) Retinopathy of prematurity General Medicine Odds ratio Oxygenation medicine.disease Confidence interval Bronchopulmonary dysplasia Anesthesia Pediatrics Perinatology and Child Health medicine Gestation business |
| Zdroj: | Acta Paediatrica. 84:913-921 |
| ISSN: | 1651-2227 0803-5253 |
| DOI: | 10.1111/j.1651-2227.1995.tb13792.x |
| Popis: | The aim of the study was to determine if prophylaxis with multiple low doses of porcine surfactant would increase survival, without bronchopulmonary dysplasia, compared with rescue therapy, for respiratory distress syndrome in newborns of 25-31 weeks’gestation. Compared with rescue therapy (n= 122), prophylaxis (n = 134) decreased the need for oxygenation and ventilatory support within 3-72 h. It did not, however, increase survival without bronchopulmonary dysplasia (60% versus 46%) (odds ratio (OR) =1.53, 95% confidence interval (CI) = 0.90-2.61). Furthermore, prophylaxis decreased the incidence of severe peri-intraventricular haemorrhage (3% versus 16%) (OR = 0.28, 95% CI = 0.09-0.84) and retinopathy of prematurity (2% versus 11%) (OR = 0.18, CI = 0.04-0.78). We conclude that prophylaxis did not increase survival without bronchopulmonary dysplasia. The decreased incidence of severe peri-intraventricular haemorrhage and retinopathy of prematurity after prophylaxis requires further study. Porcine surfactant, respiratory distress syndrome, very premature infants H Walti, Service de medecine neonatale, Hopital Cochin Port-Royal, 123 Bid de Port-Royal, 75014, Paris, France |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text