Terminal complement complex formation is associated with intervertebral disc degeneration
Autor: | Helena Brisby, Raquel Gonçalves, Rolf E. Brenner, Graciosa Q. Teixeira, Zhiyao Yong, Cornelia Neidlinger-Wilke, Anita Ignatius, Michael Ruf, Uwe Max Mauer, Amelie Kuhn, Jana Riegger, Andreas G. Nerlich, Helena Barreto Henriksson |
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Rok vydání: | 2020 |
Předmět: |
0303 health sciences
Pathology medicine.medical_specialty business.industry Inflammation Modic changes Intervertebral disc Degeneration (medical) CD59 Complement system 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure medicine Immunohistochemistry Orthopedics and Sports Medicine Surgery medicine.symptom business 030217 neurology & neurosurgery Tissue homeostasis 030304 developmental biology |
Zdroj: | European Spine Journal. 30:217-226 |
ISSN: | 1432-0932 0940-6719 |
Popis: | Purpose The complement system is a crucial part of innate immunity. Recent work demonstrated an unexpected contribution to tissue homeostasis and degeneration. This study investigated for the first time, in human disc tissues, the deposition profile of the complement activation product terminal complement complex (TCC), an inflammatory trigger and inducer of cell lysis, and its inhibitor CD59, and their correlation with the degree of disc degeneration (DD). Methods Disc biopsies were collected from patients diagnosed with DD (n = 39, age 63 ± 12) and adolescent idiopathic scoliosis (AIS, n = 10, age 17 ± 4) and compared with discs from healthy Young (n = 11, age 7 ± 7) and Elder (n = 10, age 65 ± 15) donors. Immunohistochemical detection of TCC and CD59 in nucleus pulposus (NP), annulus fibrosus (AF) and endplate (EP) was correlated with age, Pfirrmann grade and Modic changes. Results Higher percentage of TCC+ cells was detected in the NP and EP of DD compared to Elder (P P P Conclusion TCC deposition positively correlated with the degree of disc degeneration. A functional relevance of TCC may exist in DD, representing a potential target for new therapeutics. |
Databáze: | OpenAIRE |
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