Pre-engraftment graft-versus-host disease after allogeneic hematopoietic cell transplantation for acute leukemia
| Autor: | Yunsuk Choi, Kyoo Hyung Lee, Young Shin Lee, Jung-Hee Lee, Sung Cheol Yun, Je-Hwan Lee, Mi Jin Jeon, Young-Ah Kang, Miee Seol, Dae-Young Kim, Sung-Doo Kim |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Acute leukemia Neutrophil Engraftment Myeloid business.industry Myeloid leukemia chemical and pharmacologic phenomena Hematology General Medicine medicine.disease Gastroenterology Transplantation Leukemia surgical procedures operative Graft-versus-host disease medicine.anatomical_structure immune system diseases Internal medicine Immunology medicine Cumulative incidence business |
| Zdroj: | European Journal of Haematology. 87:172-181 |
| ISSN: | 0902-4441 |
| DOI: | 10.1111/j.1600-0609.2011.01646.x |
| Popis: | Objectives: Acute graft-versus-host disease (GVHD) usually occurs with neutrophil engraftment following allogeneic hematopoietic cell transplantation (HCT), but it can also occur before engraftment. We intended to analyze the effects of timing of acute GVHD on leukemia relapse and mortality. Methods: The outcomes of pre- and postengraftment GVHD were investigated in 384 patients who underwent allogeneic HCT for acute leukemia. Results: Acute GVHD occurred in 100 patients, pre-engraftment in 22 and postengraftment in 78. Compared with postengraftment GVHD, pre-engraftment GVHD was more severe, as assessed by overall grade, with more frequent and more severe skin involvement and higher incidences of non-infectious fever, diarrhea, hepatic dysfunction, renal insufficiency, and weight gain. Compared with patients without acute GVHD, those with postengraftment GVHD had lower cumulative incidence of relapse [CIR; hazard ratio (HR), 0.470; P = 0.006] and higher cumulative incidence of non-relapse mortality (CINRM; HR, 2.568; P |
| Databáze: | OpenAIRE |
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