The effects of vitamin E on platelet activity in β-thalassaemia patients

Autor: Suthat Fucharoen, Pensri Pootrakul, Udom Chantharaksri, Supeenun Unchern, Noppawan Phumala, Pornpan Sipankapracha, Wanchai Wanachivanawin, Narumol Laoharuangpanya
Rok vydání: 2003
Předmět:
Zdroj: British Journal of Haematology. 123:738-744
ISSN: 0007-1048
DOI: 10.1046/j.1365-2141.2003.04691.x
Popis: A double-blind, crossover, placebo-controlled study of the effect of vitamin E on platelet functions was performed on nine splenectomized and 16 non-splenectomized beta-thalassaemia/haemoglobin E (beta-thalassaemia/HbE) patients. The patients were supplemented with a daily dose of vitamin E (525 IU) for 3 months. The functions of platelets were assessed by adenosine diphosphate (ADP)-induced platelet aggregation and adenosine triphosphate release. Plasma alpha-tocopherol, plasma thiobarbituric reactive substances (TBARs) and serum ferritin levels represented patients' antioxidant status, lipid peroxidation status and iron status respectively. Before experimentation, all patients had low plasma alpha-tocopherol levels. The splenectomized patients showed severe iron overload iron, had higher plasma TBAR levels and their platelets were more reactive to ADP than those of non-splenectomized patients. Three months of daily vitamin E supplementation resulted in a significant increase in plasma alpha-tocopherol levels and reduction in plasma TBAR levels in all patients. Serum ferritin levels of the patients were not altered; however, vitamin E reduced the platelet reactivity of the splenectomized patients towards normal levels. The influence of vitamin E on platelet reactivity may result in delaying hypoxaemia and pulmonary occlusion that commonly occurs in splenectomized beta-thalassaemia/HbE patients.
Databáze: OpenAIRE
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