| Popis: |
Atherosclerosis and cerebrovascular disease have been reported by Wexler and True (Circ. Res. 12: 659,1963) to-occur in retired breeder rats but not in virgin rats of the same age. We have discovered that retired breeder (RB) male rats have spontaneous circulating platelet aggregates (CPA) as determined by the method of Wu and Hoak (Lancet 2: 924, 1974). These CPA respond to therapy with clinically proven antiplatelet drugs. Suloctidil (S) [l-(4-isopropyl-thiophenyl)-2-n-octylamino propanol, Continential Pharma, Brussels] administered for 8 days at 100 mg/kg i. g. showed a significant reduction in CPA from 0.76+0.05 (S.E.M.) to 0.92 + 0.03 (where 1.0 indicates no CPA). In these same rats, the endogenous platelet 5-HT level was significantly (P |
