Synthesis, study of configuration and reactivity of amino acids, acylated by p-[DI-(2-chloroalkyl)amino]cinnamic acid

Autor: L. Ya. Gurvichene, G. I. Prasmitskene, O. V. Kil'disheva, A. M. Yuodvirshis, K. I. Karpavichyus
Rok vydání: 1973
Předmět:
Zdroj: Bulletin of the Academy of Sciences of the USSR Division of Chemical Science. 22:2012-2016
ISSN: 1573-9171
0568-5230
DOI: 10.1007/bf00929394
Popis: 1. The following compounds were synthesized; p-[di-(2-chloropropyl)amino]cinnamoyl-DL-phenyl-alanine and its ethyl ester, p-[di-(2-chloropropyl)amino]cinnamoyl-DL-valine, the methyl ester of p-[di-(2-chloropropyl) amino]cinnamoyl-L-histidine, p-[di-(2-chloropropyl)amino]cinnamoyl-p-aminobenzoic acid and its ethyl ester, and also p-[di-(2-chloroethyl)amino]cinnamoyl-p-aminobenzoic acid and its ethyl ester. 2. The hydrolysis rate of the C-Cl bond in the cytotoxic groups of the synthesized compounds was measured.
Databáze: OpenAIRE