Synthesis, study of configuration and reactivity of amino acids, acylated by p-[DI-(2-chloroalkyl)amino]cinnamic acid
Autor: | L. Ya. Gurvichene, G. I. Prasmitskene, O. V. Kil'disheva, A. M. Yuodvirshis, K. I. Karpavichyus |
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Rok vydání: | 1973 |
Předmět: | |
Zdroj: | Bulletin of the Academy of Sciences of the USSR Division of Chemical Science. 22:2012-2016 |
ISSN: | 1573-9171 0568-5230 |
DOI: | 10.1007/bf00929394 |
Popis: | 1. The following compounds were synthesized; p-[di-(2-chloropropyl)amino]cinnamoyl-DL-phenyl-alanine and its ethyl ester, p-[di-(2-chloropropyl)amino]cinnamoyl-DL-valine, the methyl ester of p-[di-(2-chloropropyl) amino]cinnamoyl-L-histidine, p-[di-(2-chloropropyl)amino]cinnamoyl-p-aminobenzoic acid and its ethyl ester, and also p-[di-(2-chloroethyl)amino]cinnamoyl-p-aminobenzoic acid and its ethyl ester. 2. The hydrolysis rate of the C-Cl bond in the cytotoxic groups of the synthesized compounds was measured. |
Databáze: | OpenAIRE |
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