CONDITIONS OF MICROELEMENTS EXCHANGE PROCESSES IN WOMEN’S PLACENTS IN INTRAUTERINE INFECTION OF THE FETUS
| Autor: | Irуna M. Nikitina, Anzhelika A. Shevel, Kateryna Kondratiuk, Natalia V Kalashnyk, Svitlana Anatoliivna Smiian |
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| Rok vydání: | 2020 |
| Předmět: |
Fetus
Pregnancy Transplacental transmission business.industry Physiology General Medicine 030204 cardiovascular system & hematology medicine.disease Umbilical cord Pathogenesis 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Placenta embryonic structures Fetal distress Medicine 030212 general & internal medicine business Intrauterine infection reproductive and urinary physiology |
| Zdroj: | Wiadomości Lekarskie. 73:1434-1437 |
| ISSN: | 0043-5147 |
| DOI: | 10.36740/wlek202007123 |
| Popis: | OBJECTIVE The aim:to study the content of trace elements (Fe, Cu, Zn, Co, Cr, Ni, Pb) in the placenta of pregnant healthy women and with signs of intrauterine infection of the fetus, features of transplacental transmission of infectious process from mother to fetus and to investigate the role of the placenta in trace element supply of the fetus. PATIENTS AND METHODS Materials and methods. 43 pregnant women between the aged 16 to 40 years were monitored, including 12 with physiological pregnancy (group 1) and 31 with signs of STI (group 2). All pregnant women underwent standard comprehensive examination, evaluation of fetal cardiac output and non-stress testing using cardio-toсography (CTG) in the third trimester. The group of pregnant women with signs of fetal ulcers included women whose pregnancy was complicated by chronic fetoplacental dysfunction (FPD), infectious lesions of the fetoplacental complex, which were diagnosed on the basis of ultrasound signs of placenta, syndrome of infectious and surrounding infections. RESULTS Results:The content of essential trace elements in the placenta of the main group was significantly lower than in the placenta of the control group. There was a decrease in the concentration of iron by 32%, zinc - by 46%, nickel - by 44%, copper more than tripled, chromium - 4 times. Deficiency of essential trace elements (iron, zinc, copper, chromium, nickel) and elevated lead content in the placenta leads to the formation of conditions for the development of placental dysfunction, the progression of which leads to fetal distress, developmental delay syndrome and antenatal fetal death. CONCLUSION Conclusions:1. One of the links in the pathogenesis of intrauterine infection in the fetus is the imbalance of essential trace elements in the system «mother - placenta - fetus». 2. Pregnant women with signs of intrauterine infection are characterized by a deficiency of serum Fe, Cu, Zn, Ni and an increased content of Pb, Cr and Co compared with pregnant women with physiological pregnancy. 3. Umbilical cord blood of women with evidence of fetal fetal infection also has a reduced content of iron, copper, zinc and high levels of lead, cobalt and chromium. 4. Disruption of placental function in intrauterine infection of the fetus is caused by reduced content of iron, zinc, copper, nickel and lead accumulation. |
| Databáze: | OpenAIRE |
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