Liquid chromatographic separation of the enantiomers of cyclic β-amino esters as their N-3,5-dinitrobenzoyl derivatives

Autor:	William E. Bowen, William H. Pirkle, Duc V. Vuong
Rok vydání:	1994
Předmět:	Chromatography Amino esters Organic Chemistry General Medicine Biochemistry Isocyanate High-performance liquid chromatography Cycloaddition Analytical Chemistry Chiral column chromatography chemistry.chemical_compound chemistry Organic chemistry Enantiomer Chiral derivatizing agent Derivatization
Zdroj:	Journal of Chromatography A. 676:297-302
ISSN:	0021-9673
DOI:	10.1016/0021-9673(94)80429-x
Popis:	A variety of cyclic N-3,5-dinitrobenzoyl β-amino esters has been synthesized and resolved by chiral HPLC. The β-amino esters were derived from β-lactams formed by the [2+2] cycloaddition of N-chlorosulfonyl isocyanate with simple olefins. Chromatographic separation of the enantiomers of these N-(3,5-dinitrobenzoyl)-β-amino esters on three π-basic chiral stationary phases is described and the origin of the observed chiral recognition considered.
Databáze:	OpenAIRE
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