The effects of glucocorticoid therapy on glucocorticoid receptors in leukemia and lymphoma
| Autor: | Clara D. Bloomfield, G. F. Shipman, Kendall A. Smith, Bruce A. Peterson, Allan U. Munck |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
medicine.medical_specialty
business.industry Immunology Cell Cell Biology Hematology medicine.disease Biochemistry Peripheral blood Lymphoma Leukemia Glucocorticoid receptor Endocrinology medicine.anatomical_structure Glucocorticoid therapy Internal medicine medicine Receptor business hormones hormone substitutes and hormone antagonists Glucocorticoid medicine.drug |
| Zdroj: | Blood. 58:1198-1202 |
| ISSN: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood.v58.6.1198.bloodjournal5861198 |
| Popis: | Measurement of glucocorticoid receptors appears to be useful for selecting which patients with leukemia and lymphoma should receive glucocorticoid therapy. To determine the effect of recent or concurrent glucocorticoid therapy on the number of measured tumor glucocorticoid receptor sites, 18 patients with leukemia and lymphoma were studied. Baseline determinations of numbers of glucocorticoid receptors were performed on the malignant cells circulating in the patients' peripheral blood. Glucocorticoid therapy was then instituted consisting of dexamethasone 4 mg p.o. every 6 hr. Repeat determinations of the number of glucocorticoid receptor sites were performed within 24 hr and at various subsequent times from the start of therapy. When compared to baseline receptor numbers, 16 of 18 patients demonstrated a decrease in receptor number (median decrease 1651 sites/cell) after the start of glucocorticoid therapy. The magnitude of the change in receptor number was independent on the initial number of receptors. Our results suggest that in order accurately interpret glucocorticoid receptor numbers in patients with leukemia and lymphoma, glucocorticoid should not be administered for 3 wk prior to determinations of receptor levels. |
| Databáze: | OpenAIRE |
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