The effects of sub-acute administration of triiodothyronine (T3) on the acute toxicity of lithium in the rat
| Autor: | B. Shopsin, I. Sanghvi, Samuel Gershon |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
medicine.medical_specialty
Triiodothyronine Lithium (medication) business.industry General Medicine Sub acute Pharmacology General Biochemistry Genetics and Molecular Biology Acute toxicity Endocrinology Internal medicine Toxicity Medicine General Pharmacology Toxicology and Pharmaceutics Once daily business medicine.drug |
| Zdroj: | Life Sciences. 10:1217-1223 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(71)90291-8 |
| Popis: | The effects of sub-acute administration of triiodothyronine (T3) on acute toxicity of lithium and body temperature were investigated in male Sprague-Dawley rats. T3 in doses of 0.1 and 1.0 mg/kg when given intraperitoneally once daily for six days increased the toxicity of acute lithium administration. The hypothermic effect of lithium, on the other hand, was prevented by sub-acute administration of T3. Thus, on acute toxicity, lithium and T3 were synergistic while on the temperature, they were antagonists. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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