Novel synthesis of 1α,25-dihydroxy-19-norvitamin D from 25-hydroxyvitamin D

Autor:	Kazuo Nagasawa, Hazuki Nagai, Asako Toyoda, Tomonari Yamada, Toshio Tsuchida, Junko Abe, Yusuke Moriguchi
Rok vydání:	2009
Předmět:	Olefin fiber Bioconversion Stereochemistry Chemistry medicine.medical_treatment Organic Chemistry Regioselectivity Biochemistry Chemical synthesis Steroid Hydroboration Drug Discovery Vitamin D and neurology medicine Stereoselectivity
Zdroj:	Tetrahedron. 65:10002-10008
ISSN:	0040-4020
DOI:	10.1016/j.tet.2009.09.115
Popis:	19-Norvitamin D analogs 3a and 3b were synthesized from 25-hydroxyvitamin D, obtained via a bioconversion method. The synthetic route features a highly regio- and stereoselective hydroboration reaction to afford 25-hydroxy-3,5-cyclopropyl-vitamin D derivatives 12 having olefin at the C1–10-position.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5497a5587f88c665b46b68f80d77eb31 https://doi.org/10.1016/j.tet.2009.09.115 Zobrazit plný text záznamu Full Text from ScienceDirect